Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding

Yufan He, Nikita Zalenski, Adarsh Kumar, Anthony A. Stephenson, Austin T. Raper, Chiran Ghimire, Zucai Suo

Under communication

Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator

Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H.M. Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann

Journal of Medicinal Chemistry, vol. 67, 2024, pp. 4691-4706

Structure-based design of PROTACs for the degradation of soluble epoxide hydrolase

J. Schönfeld, S. Brunst, L. Ciomirtan, N. Liebisch, A. Kumar, J. H. M. Ehrler, L. Wintermeier, J. Heering, A. Brüggerhoff, L. Weizel, A. Kaiser, M. Schubert-Zsilavecz, S. Knapp, R. Fürst, E. Proschak, K. Hiesinger

bioRxiv, 2024

Stoichiometry of ligand binding and role of C-terminal lysines in Mycobacterium tuberculosis and human GAPDH multifunctionality

Ajay Kumar, Rajender Kumar, Vishant Mahendra Boradia, Himanshu Malhotra, Adarsh Kumar, Sriraj Seth, Prabha Garg, Subramanian Karthikeyan, Manoj Raje, Chaaya Iyengar Raje

The FEBS Journal, n/a, 2024

Photosensitization enables Pauson-Khand–type reactions with nitrenes

Fang Li, W. Felix Zhu, Claire Empel, Oleksandr Datsenko, Adarsh Kumar, Yameng Xu, Johanna H. M. Ehrler, Iuliana Atodiresei, Stefan Knapp, Pavel K. Mykhailiuk, Ewgenij Proschak, Rene M. Koenigs

Science, vol. 383, 2024, pp. 498-503

The catalytic domain of free or ligand bound histone deacetylase 4 occurs in solution predominantly in closed conformation

Markus Schweipert, Thomas Nehls, Anton Frühauf, Cecilé Debarnot, Adarsh Kumar, Stefan Knapp, Frederik Lermyte, Franz-Josef Meyer-Almes

Protein Science, vol. 33, 2024, pp. e4917

Photosensitization Enables Pauson-Khand-type Reactions with Nitrenes

Fang Li, W. Felix Zhu, Claire Empel, Oleksandr Datsenko, Adarsh Kumar, Yameng Xu, Johanna H. M. Ehrler, Iuliana Atodiresei, Stefan Knapp, Pavel K. Mykhailiuk, et al.

ChemRxiv, Cambridge Open Engage, 2023

Targeting LC3/GABARAP for degrader development and autophagy modulation

Martin P. Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A. Greco, Nicolas Bauer, Frank L{\"o}hr, Jan Heering, Sara Cano, Severin Lechner, Thomas Hanke, Ivana Bekic, Viktoria Morasch, Daren Fearon, Peter G. Marples, Charles W. E. Tomlinson, Lorene Brunello, Krishna Saxena, Nathan Adams, Frank von-Delft, Susanne M{\"u}ller, Alexandra Stolz, Ewgenij Proschak, Bernhard Kuster, Stefan Knapp, Vladimir V. Rogov

bioRxiv, Cold Spring Harbor Laboratory, 2023

Interlocking activities of DNA polymerase β in the base excision repair pathway

Adarsh Kumar, A. Reed, Walter J. Zahurancik, S. Daskalova, S. Hecht, Z. Suo

Proceedings of the National Academy of Sciences of the United States of America, 2022

Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis

Adarsh Kumar, Subramanian Karthikeyan

Acta Crystallographica Section F, vol. 74, 2018 Mar, pp. 166--173

Structural and mechanistic insights into Rv2229c, an essential gene from Mycobacterium tuberculosis

Adarsh Kumar

CSIR-IMTECH, Chandigarh/Jawaharlal Nehru University, New Delhi, 2017

Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-butanone-4-phosphate Synthase from Vibrio cholerae*

Zeyaul Islam, Adarsh Kumar, Suruchi Singh, Laurent Salmon, Subramanian Karthikeyan

Journal of Biological Chemistry, vol. 290, 2015, pp. 11293-11308