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Dr. Adarsh Kumar

Transforming Protein Structures into Therapeutic Breakthroughs | Structural Biology | Drug Discovery | Crystallographic Fragment Screening | Molecular Biology | Biochemistry

Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids


Journal article


Joel L. Syphers, Josephine A. Wright, Rebekah {de Nys}, Tharindie N. Silva, Laura Vrbanac, Kate R. Barratt, Julia Leeflang, Sadia T. Hasan, Sophie F. Thomson, Adarsh Kumar, Andreas Krämer, Christopher Lenz, Yi Sing Gee, Aeson Chang, Savannah Young, Erica K. Sloan, Stefan Knapp, Daniel L. Worthley, Siddhartha Mukherjee, Kieran Stockton, Daniel L. Priebbenow, Susan L. Woods, Jonathan B. Baell
European Journal of Medicinal Chemistry, vol. 312, 2026, p. 118838


Cite

Cite

APA   Click to copy
Syphers, J. L., Wright, J. A., {de Nys}, R., Silva, T. N., Vrbanac, L., Barratt, K. R., … Baell, J. B. (2026). Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids. European Journal of Medicinal Chemistry, 312, 118838. https://doi.org/10.1016/j.ejmech.2026.118838


Chicago/Turabian   Click to copy
Syphers, Joel L., Josephine A. Wright, Rebekah {de Nys}, Tharindie N. Silva, Laura Vrbanac, Kate R. Barratt, Julia Leeflang, et al. “Discovery of APO-50815, a Potent WEE1 Kinase Inhibitor with Exceptional Efficacy against Patient-Derived Colorectal Cancer Organoids.” European Journal of Medicinal Chemistry 312 (2026): 118838.


MLA   Click to copy
Syphers, Joel L., et al. “Discovery of APO-50815, a Potent WEE1 Kinase Inhibitor with Exceptional Efficacy against Patient-Derived Colorectal Cancer Organoids.” European Journal of Medicinal Chemistry, vol. 312, 2026, p. 118838, doi:10.1016/j.ejmech.2026.118838.


BibTeX   Click to copy

@article{syphers2026a,
  title = {Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids},
  year = {2026},
  journal = {European Journal of Medicinal Chemistry},
  pages = {118838},
  volume = {312},
  doi = {10.1016/j.ejmech.2026.118838},
  author = {Syphers, Joel L. and Wright, Josephine A. and {de Nys}, Rebekah and Silva, Tharindie N. and Vrbanac, Laura and Barratt, Kate R. and Leeflang, Julia and Hasan, Sadia T. and Thomson, Sophie F. and Kumar, Adarsh and Krämer, Andreas and Lenz, Christopher and Gee, Yi Sing and Chang, Aeson and Young, Savannah and Sloan, Erica K. and Knapp, Stefan and Worthley, Daniel L. and Mukherjee, Siddhartha and Stockton, Kieran and Priebbenow, Daniel L. and Woods, Susan L. and Baell, Jonathan B.}
}



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